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Case & Family Studies
(country then alphabetical order)
Countries:
Australia
- Australian and New Zealand Clinical Trials Registry (ANZCTR):
“The ANZCTR will include information about: clinical trials into
pharmaceuticals, surgical procedures, preventive measures,
lifestyle, devices, rehabilitation strategies and complementary
therapies; and all clinical trials involving Australian
researchers and participants and covering all areas of health.
Case selections based on genetic criteria, and other genetic
studies are now relevant to numerous trials.” -
http://www.actr.org.au/actr/handler?Action=home
- Hunter DNA Bank for Schizophrenia and Allied Disorders:
“The DNA Bank has been established in the first instance in the
Hunter region, where sufficiently large samples of people with
schizophrenia and their families are located. Volunteers with
schizophrenia, their first-degree relatives and people without a
personal or family history of mental illness will be recruited
through the resources of the NISAD Schizophrenia Research
Register. The facilities of the Medical Genetics laboratory,
situated at the John Hunter Hospital in Newcastle, will be used
to process the blood samples. Genomic DNA, RNA and lymphocytes
will be isolated and stored. The samples will then be made
available for research projects investigating the genetics of
schizophrenia. Researchers wishing to use these samples would be
required to apply to the DNA Bank for Schizophrenia Research for
permission, giving details of the proposed project.” -
http://www.newcastle.edu.au/centre/cmhs/projects/nisadd.html
Denmark
- Danish Twin Registry:
“The Danish Twin Registry (DTR) is one of the oldest twin registries in
the world. It was established in the 1950’es with the aim of studying causes of
cancer, and through the years it has gradually been expanded so that it now
comprises twins born through more than 130 years." -
http://www.dtr.sdu.dk/?sideid=index&sprog=eng
EIRE
- Pharmacogenetics of Vascular Disease - RCSI, Dublin,
Eire: “bioresources at SurGen: hypertension and metabolic
syndrome phenotypes on 1,400 normal subjects, 125 BPU
hypertensives, 260 SPP100-04 hypertensives; ASCOT 6yeay
follow-up on 9,500 hypertensives; ASCOT HACVD detailed cv risk
data on 1,000 hypertensives. ADVANCE (with Sydney, Australia)
10,000 diabetics 5 year follow-up. 2,000 pateints with regular
retinal photography. 400 patients with regular oxidative stress
measurements.” -
http://www.inst-biopharmsci.org/subhtml/projects_stanton.htm
Finland
- Botnia Study (type 2 diabetes): "The Botnia Study was begun in 1990 in Pohjanmaa,
Finland. From five public health care districts (Malax, Korsholm, Närpes,
Jakobstad, Vasa) all the people suffering from adult-onset (type 2) diabetes and
their families were invited to participate in the study. In 1994 the study was
expanded to the rest of Finland and to the south of Sweden (so called
SIB-study). Altogether more than 9000 persons from 1400 families have
participated in the study. During the last few years the study has expanded to
people with young-onset (type 1) diabetes." -
http://www.botnia-study.org/e/index.html
Germany
- Baden-Württemberg consortium on Addiction: “The DNA
bank "Addiction" collects blood and extracts DNA of the samples
recruited by the Baden-Württemberg consortium on addiction
research. Furthermore, genotyping and association analyses of
functionally related candidate genes of neurosignalling pathways
relevant to addiction are being performed.” -
http://www.zi-mannheim.de/808.html
Holland
- Dutch Twin Registry:
“Het
Nederlands Tweelingen Register (kortweg NTR) werd op 1 februari 1987 aan de
Vrije Universiteit te Amsterdam opgericht ten behoeve van
wetenschappelijk onderzoek. Onderzoek bij tweelingen en hun familieleden kan
namelijk inzicht verschaffen in de mate waarin verschillen tussen mensen bepaald
worden door erfelijke of omgevingsinvloeden. Door de continue hulp van de
tweelingen en hun families die bij het NTR staan ingeschreven onderzoekt het NTR
de invloed van genen en omgeving op onder andere de ontwikkeling van de hersenen,
intelligentie, probleemgedrag van kinderen, gezondheid en leefgewoonten, angst
en depressie, persoonlijkheid en veroudering." -
http://www.tweelingenregister.org/
Italy
International
- European Type 1 Diabetes Genetics Network: “The
ET1DGN is part of the international effort of the Type 1
Diabetes Genetics Consortium (T1DGC) to identify and collect
families in which at least 2 siblings suffer from type 1
diabetes, in order to search for genetic markers of the disease.
The project is carried out in collaboration with other regional
networks (Latin-America, Asia Pacific, North America and United
Kingdom) and is funded by the NIH. The aim of the ET1DGN is to
recruit at least 1200 families in the European region,
representing as diversified a population as possible in order to
secure a broad scientific base. To achieve its goals, the ET1DGN
seeks to establish, maintain and promote a network of
collaborating centers in as many European countries as possible”
- http://et1dgn.org/
- GenomEUtwin: “The participating 8 twin cohorts form a
collection of over 0.6 million pairs of twins. Tens of thousands
of DNA samples with informed consents for genetic studies of
common diseases have already been stored from these
population-based twin cohorts. The population cohorts used in
the Genomeutwin study consist of Danish, Finnish, Italian, Dutch
and Swedish twins and the MORGAM population cohort." -
http://www.genomeutwin.org/index.htm
- International Multi-center ADHD Genetics Project (IMAGE):
“The Neuropsychiatric Genetics group at TCD have been funded by
the US National Institute of Mental Health over a five year
period to take part in the IMAGE programme on the Genetics of
ADHD. This major international project is a collaboration
between Trinity College, the Institute of Psychiatry in London,
the Harvard Medical School/Massachusetts General Hospital and
clinical centres throughout Europe. More information at
http://www.tcd.ie/Psychiatry/Neuropsychiatry/IMAGE.pdf” -
http://www.tcd.ie/Psychiatry/Neuropsychiatry/image.htm
- International Myeloma Foundation DNA Bank: “More than
3,000 DNA samples have been collected so far from myeloma
patients in groups that have been treated with conventional
medications, high dose therapies or with the novel medications.
The samples along with the custom gene chip analyzers and other
high tech equipment are housed at the University of Minnesota
under the direction of Dr. Van Ness, and at the Institute of
Cancer Research in London under the direction of Dr. Morgan. The
International Myeloma Foundation expects the number of samples
collected to double in the next two years” -
http://www.myeloma.org/main.jsp?type=article&id=1660
- MIRAGE (Multi Institutional Research of Alzheimer Genetic
Epidemiology) Project: “The MIRAGE (Multi
Institutional Research of Alzheimer Genetic Epidemiology)
Project, funded by the National Institute on Aging since 1991,
is the largest genetic epidemiology study of AD in the world. 12
center study of gene-environment interaction between USA, Canada
and Germany.” - http://genetics.bumc.bu.edu/research/alzres.htm
- Type 1 Diabetes Genetics Consortium (T1DGC): “The
international Type 1 Diabetes Genetics Consortium (T1DGC) is a
collaborative group formed to facilitate the genetic analysis of
Type 1 diabetes (T1D) via the sharing of reagents, methods,
strategies, samples, knowledge and data at all levels. There are
extensive ongoing further colelctions, linkage and whole genome
association scans for thousands of affected sib pairs and
nuclear families. Consortium agreement at
http://www.t1dgc.org/docs/T1DGC_Consortium_Agreement.pdf” -
http://www.t1dgc.org/
- WHO International Clinical Trials Registry Platform (ICTRP):
“World Health Organisation portal for Clinical Trials.
Numerous therapeutic trials now have genetic selection criteria
or use genetic studies as part of design or follow up.” -
http://www.who.int/ictrp/en/
Japan
- JSSLG - Japanese Schizophrenia Sib-Pair Linkage Group:
“The Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) is a
multisite collaborative study group that was organized to create
a national resource for affected sib pair (ASP) studies of
schizophrenia in Japan. We used a high-density single-nucleotidepolymorphism
(SNP) genotyping assay, the Illumina BeadArray linkage mapping
panel (version 4) comprising 5,861 SNPs, to perform a genomewide
linkage analysis of JSSLG samples comprising 236 Japanese
families with 268 nonindependent ASPs with schizophrenia. All
subjects were Japanese.” -
http://www.journals.uchicago.edu/cgi-bin/resolve?id=doi:10.1086/498122
New Zealand
- Australian and New Zealand Clinical Trials Registry (ANZCTR):
“The ANZCTR will include information about: clinical trials into
pharmaceuticals, surgical procedures, preventive measures,
lifestyle, devices, rehabilitation strategies and complementary
therapies; and all clinical trials involving Australian
researchers and participants and covering all areas of health.
Case selections based on genetic criteria, and other genetic
studies are now relevant to numerous trials.” -
http://www.actr.org.au/actr/handler?Action=home
Philippines
- Clefts of the lip and palate "are common human birth defects of
multifactorial etiology and with important surgical, medical, speech, behavioral
and developmental implications. Currently, we are carrying out an expanded case
ascertainment using both surveillance systems in the United States and overseas,
particularly in the Philippines under the auspices of Operation Smile."
http://genetics.uiowa.edu/projects/projectDescriptions/MolEpiCLP.htm
Sweden
- Botnia Study (type 2 diabetes): "The Botnia Study was begun in 1990 in Pohjanmaa,
Finland. From five public health care districts (Malax, Korsholm, Närpes,
Jakobstad, Vasa) all the people suffering from adult-onset (type 2) diabetes and
their families were invited to participate in the study. In 1994 the study was
expanded to the rest of Finland and to the south of Sweden (so called
SIB-study). Altogether more than 9000 persons from 1400 families have
participated in the study. During the last few years the study has expanded to
people with young-onset (type 1) diabetes." -
http://www.botnia-study.org/e/index.html
- The Swedish Twin Registry "is the largest twin register in the world and
includes more than 140,000 twins. The registry covers three different age
cohorts, the older cohort, the middle cohort, and the younger cohort. The
purpose of twin studies is to study the relative importance of genetic and
environmental influences for behavioral characteristics and diseases. There are
about 30 ongoing research projects using data from the Swedish Twin Registry." -
http://www.meb.ki.se/twinreg/index_en.html
United Kingdom
- The British Genetics of Hypertension (BRIGHT) study -
"...a research
collaboration between 6 UK universities with the aim of finding genes
causing high blood pressure using large-scale family studies. We hope that
the discovery of genes causing high blood pressure will ultimately lead to
new diagnostics, improved therapeutic targets and better prediction of those
at greatest risk". http://www.brightstudy.ac.uk/
- Catalogue of MRC funded UK DNA Banking
Network Case studies: "In 2000 the draft sequence of the human genome
was published and the UK MRC identified genetic epidemiology as a strategically
important area for translating knowledge of the human genome sequence into real
benefits for human health. MRC made awards that year to enable collection of
large numbers of samples in 13 common diseases of major public
health impact. For further details on each study see the
catalogue. These samples were to be managed centrally as
national resources and be made widely available." -
http://www.dna-network.ac.uk/Studies/
- Current Controlled Trials (UK): “Current Controlled
Trials allows users to search, register and share information
about randomised controlled trials. Access to all the
information on this site is free; charges for the registration
services offered by Current Controlled Trials are available on
request. Case selection based on genetic criteria and genetic
studies in general, are now relevant to numerous trials.” -
http://www.controlled-trials.com/
- Glomurulonephritis national DNA bank: “DNA from over
2,500 probands and controls has been banked. The bank is
probably the largest collection of DNA from patients with
glomerular disease in the world but is still being expanded.The
objective was to collect and archive DNA together with EBV
transformed cell lines, serum and clinical data from a
sufficiently large cohort of patients to enable suitably
empowered genetic studies to be performed on five of the most
common types of glomerulonephritis: - IgA nephropathy,
membranous nephropathy, focal necrotising glomerulonephritis (FNGN),
lupus nephropathy and minimal change nephritic syndrome.” -
http://www.renal.org/Research/GN-DNAbank.html
- Insitute of Cancer Research UK collections "(numerous cancer types) Non-medullary
thyroid cancer (NMTC) Chronic Lymphocytic Leukaemia (CLL)[International
Consortium to collect multiple case families]Collaborative venture between The
Institute and the Royal Marsden a DNA and family history register of the Royal
Marsden patients for a wide range of cancers.Colorectal Cancer Susceptibility
CORGI (ColORectal tumour Gene Identification) study. “Normal and tumour tissue
have been obtained from a random subset of 1,000 patients entered into a trial
of 10,000 colorectal cancer patients evaluating use of 5-FU. Using this resource
we are exploring if tumour genotypes can predict prognosis or response to
therapy.”Proteus Syndrome Juvenile Polyposis Peutz-Jeghers Syndrome Multiple
Leiomyomatosis Neurofibromatosis (NF) type 1 Lung Cancer Susceptibility [GELCAPS
consortium]" -
http://www.icr.ac.uk/cancgen/molgen/mgteam.htm
- The National Research Register (NRR) UK: "is a database of ongoing and
recently completed research projects funded by, or of interest to, the United
Kingdom's National Health Service (NHS. About 350 organisations (NHS Trusts,
national and regional funding programmes, universities, charities) in England,
Scotland and Wales contribute data which is updated every three months. The
Register provides a reasonable record of projects that were ongoing from early
2000 onwards..." - http://www.nrr.nhs.uk/
- Oxford Regional Prospective Study (ORPS) and UK
Nephropathy Family Study (NFS): “The risk of serious
diabetic complications has been much reduced by recent
improvements in achieving good control of blood glucose in
children with diabetes. However, a few children will still
develop problems with their kidneys and eyes when they become
adults. As well as being related to blood glucose levels, the
risk of complications may be partly inherited. Some of the genes
may determine the risk of developing complications. Small leaks
of protein in the urine of children and adolescents with
diabetes (microalbuminuria) may be the first marker of the later
risk for complications. We plan to investigate the relationship
between protein in the urine of children with diabetes and blood
pressure, blood fats and urinary protein excretion in their
parents. We will also study the genes in the parents and the
children to see if they explain these relationships. The study
has recruited 1,000 children who are being followed up for four
years to see how they progress.” -
http://www-gene.cimr.cam.ac.uk/ucdr/neph.shtml
- Twin Research UK: “We provide a list of the vast majority of phenotypes
that have been collected on at least 1,000 individuals in the Twins UK study" -
http://www.twin-research.ac.uk/
- UK GRID: Genetic Resource Investigating Diabetes:
“The UK GRID Project was set up to collect blood samples from
very large numbers of patients with type 1 diabetes, and in some
cases, their family members, in order to conduct large-scale
studies into the genetics of type 1 diabetes. For the purposes
of the study, we have divided the United Kingdom into fifteen
distinct regions. Each region has a "Lead Clinician(s)", who
helps recruit and coordinate the other centres in their area.
These regional structures will also be used in the planning of
the Children's Diabetes Register. GRID encompasses two main
studies: a collection of samples from 8,000 people, mostly
children, with type 1 diabetes (the National DNA Collection);
and 1,500 families, with a child with type 1 diabetes and
followed for some time during the study for factors that might
allow us to predict the possible future development of diabetic
complications (the Oxford Regional Prospective Study, ORPS and
the Nephropathy Family Study, NFS).” -
http://www-gene.cimr.cam.ac.uk/ucdr/grid.shtml
- Vesicoureteric Reflux (VUR) ASPs/nuclear families:
“It is our aim to collect blood samples and data relating to
disease, diagnosis, progression and treatment of VUR from 300
families – MOTHER, FATHER, INDEX CASE AND AFFECTED SIBLING(S).
These families will be retrieved from the BAPN renal units and
other interested physicians across the UK. To date (2005) we
have identified 170 families, contacted150, replies from 140 and
blood samples from 110.” -
http://www.britishrenal.org/conferences/brs2004/Poster%20Abstracts/Pre%20Dial%202.pdf
United States of America
- AGRE - autism genetic resource exchange: "The goal of AGRE is to facilitate more
rapid progress in the identification of the genetic underpinnings of autism and
Autism Spectrum Disorders by making this information available to the scientific
community. This substantial collection, has now grown to almost 700 multiplex
and simplex families." - http://www.agre.org/index.cfm
- Atherosclerosis Risk in Communities (ARIC) Ancillary
Study of Susceptibility Genes for Diabetes, Obesity, and
Hyperinsulinemia: “Included were 11,475 whites and 4,260
African-Americans aged 45-64 at baseline (1986-89), from four
U.S. communities--Washington County, MD (Johns Hopkins); Forsyth
County, NC (Bowman-Gray/University of North Carolina); Jackson,
MI (University of Mississippi); and suburban Minneapolis, MN
(University of Minnesota). Data collected at baseline included
... <4 repeat visits up to 2004>. Diabetes risk substudy to
identify associations between functional variants (if known) or
estimated haplotypes in candidate susceptibility genes and the
risk of type 2 diabetes in a community-based sample of
approximately 9000 middle-aged adults from the ARIC cohort.” -
http://www.jhsph.edu/cvdepi/Research_Projects/Research%20Projects%20Descriptions
- Breast, ovarian and colon cancer: "North American
family registries for breast/ovarian and colon cancer" -
http://epi.grants.cancer.gov/CFR/
- Clefts of the lip and palate "are common human birth defects of
multifactorial etiology and with important surgical, medical, speech, behavioral
and developmental implications. Currently, we are carrying out an expanded case
ascertainment using both surveillance systems in the United States and overseas,
particularly in the Philippines under the auspices of Operation Smile."
http://genetics.uiowa.edu/projects/projectDescriptions/MolEpiCLP.htm
- ClinicalTrials.gov / US NIH listing of registered
clinical trials: “ClinicalTrials.gov provides regularly
updated information about federally and privately supported
clinical research in human volunteers, observational as well as
drug trials. ClinicalTrials.gov gives you information about a
trial's purpose, who may participate, locations, and phone
numbers for more details. Trial protocol information is also
given. Note that many trials now collect DNA. There is a search
engine, a search on the word 'genetic' brings up >700 entries.”
-
http://www.clinicaltrials.gov/
- Collaborative Study on the Genetics of Alcoholism (COGA) study: "The
Collaborative Study on the Genetics of Alcoholism (COGA) study assessed 987
individuals from 105 multigenerational families selected through 23 female and
82 male adults in metropolitan inpatient and outpatient alcoholism treatment
programs. Each of the 105 families contained at least three first-degree
relatives with alcohol dependence. Like alcoholics in the general U.S.
population, the study group was predominantly Caucasian and evidenced
considerable comorbidity with other psychiatric diagnoses. COGA investigators
now are analyzing results from a second scan in a similarly ascertained
replication sample with 157 families and 1313 informative members." -
http://www.niaaa.nih.gov/ResearchInformation/ExtramuralResearch/SharedResources/projcoga.htm
- Flint Men's Health Study (African-Americans /prostate
cancer): “The study began collecting data in 1996 and
identified 817 eligible African-American men ages 40-79 to
participate. The study subjects were recruited from Flint, Mich.,
an urban area north of Detroit. Of the eligible group, 369
participants underwent an interview, clinical exam and serum
test. Researchers contacted the participants again in 2000 for
further testing; 183 took part in the second wave.” -
http://www.mydna.com/health/prostate_cancer/ethnicity/msr1pc.html
- GALA - Genetics of Asthma in Latino Americans: “It is
now well established that among U.S. residents of similar
socio-economic status, there is greater asthma morbidity and
mortality among Latino Americans and African Americans than
among Caucasian Americans; and specifically, reported rates of
asthma morbidity and mortality are higher among Puerto Rican
Americans than among Mexican Americans. We will recruit Latino
American asthmatic children (probands) and their biologic
parents (n=2400) from California, New York, Mexico City and
Puerto Rico during a 2 year period. Probands will undergo formal
phenotypic characterization.” -
http://pulmonary.ucsf.edu/research/gala.html
- Genetics of Kidneys in Diabetes Study (GoKinD):
“GoKinD has recruited over 2,700 participants including 243 case
subjects with two parents (trios), 283 control-subject trios,
559 case-subject singletons, and 565 control-subject singletons.
In all, this collection includes 802 individuals with both T1D
and renal disease and 848 individuals with T1D and no renal
disease. It will also include 1650 individuals with T1D and 526
T1D trios. Recruitment of new families for the study is closed
as of November 2004. In the three and a half years of the
recruitment phase the GoKinD study has screened more than 5500
participants by phone and in person.” -
http://www.gokind.org/access/home.html
- ISGS - Ischaemic Stroke Genetics Study (protocol):
“All protocols for the Ischemic Stroke Genetic Study - this is a
prospective, multicenter genetic association study in adults
with recent first-ever ischemic stroke confirmed with computed
tomography or magnetic resonance imaging. Patients are evaluated
at academic medical centers in the United States and compared
with sex- and age-matched controls. Stroke subtypes are
determined by central blinded adjudication using standardized,
validated mechanistic and syndromic classification systems.
Immortalized cell lines are created” -
http://www.biomedcentral.com/1471-2377/3/4
- MS DNA bank - UCLA: “So far, Hauser has banked
material from hundreds of families, totaling thousands of
individuals, and including approximately 1,000 people with MS.
Based on analyses of the first 180 families, Hauser’s team is
focusing on six regions that seem to have the greatest
likelihood of contributing to the risk of MS.” -
http://www.nationalmssociety.org/pdf/research/ResearchHighlightsSummerFall02.pdf
- The National Birth Defects Prevention Study Centralized
Laboratory: “Over 5,000 specimens were received last year at
CDC. Since its inception, the NBDPS Centralized Laboratory has
received at least 6,000 buccal specimens, and 95.1 % of DNA
samples have successfully passed the quality-control process.
This high success rate will enhance the utility of this resource
in investigations of genetic risk factors for birth defects.
Slide information at www.mass.gov/dph/fch/birthdefects/mcbdrp_09_04.ppt”
-
http://www.cdc.gov/genomics/activities/ogdp/2004/eoipcoc.htm
- Parkinson's Disease Molecular Epidemiology (NIEHS
funded): “The aim of this research is to discover genes
which modify risk for Parkinson's disease. The study includes
800 patients with Parkinson's disease, and their estimated 1,222
available siblings. Common variations of at least 9 genes will
be studied, including genes associated with personality,
substance use, and anxiety and depression” -
http://www.clinicaltrials.gov/ct/show/NCT00042107
- Pharmacogenomics and Risk of Cardiovascular
Disease:
“The main objective of PARC is to both define and confirm the
genetic contribution to the large inter-individual variability in the effects
statin drugs on cardiovascular disease risk. The analyses have been based on
measurements of lipoproteins and other cardiovascular risk markers in a cohort
of 944 Caucasians and African-Americans who were treated with simvastatin 40
mg/day in a carefully supervised six-week trial. Linkage disequilibrium analysis
of SNPs identified in a total of 78 genes was used to determine 891 tag sites
that were genotyped in the first half of the cohort. In addition, we have
completed pilot studies of pharmacogenetics of blood pressure response to ACE
inhibitors in two study cohorts. In total, these studies will result in deposits
in the PharmGKB database of nearly 800,000 individual genotypes as well as the
measured phenotypes from both the statin and ACE inhibitor trials." -
http://www.pharmgkb.org/network/members/parc.jsp#team
- Project SUGAR: “African American patients with
diabetes and obesity, as well as their families, living on or
near barrier islands along the SC coast (“Sea Islands”) are
recruited through clinics, churches, community centers, and
other health organizations serving these communities. The Sea
Islanders are descendants of people transported from the
rice-growing areas of West Africa who have inhabited the islands
since the early 1700s. characterized by the highest degree of
genetic homogeneity among African Americans and a very low
degree of Caucasian admixture as well as large, stable
multi-generation families, a diet that is uniformly high in fat
content, and a common cultural identity and dialect (Gullah)
corresponding to their West African origins. More than 425
families have been enrolled, and more than 1,200 family members
have been fully phenotyped including >800 with Type 2 diabetes.”
-
http://research.musc.edu/bp/spec_sugar.html
- Prostate Cancer Studies / National Cancer Institute USA:
“Case-Control Study in Shanghai: 237 cancer cases, 206
patients with benign prostatic hyperplasia, and 471 healthy
controls randomly selected from the population. Ghana Prostate
Cancer Study. Accra. 500 cases. 1,000 controls. PSA, examination
(+/-biopsy), questionnaire.Hormonal/biochemical markers. 1,400
cases and 1,400 controls within the Prostate, Lung, Colorectal,
and Ovarian (PLCO) Cancer Screening Trial for roles of insulin
resistance and inflammation. NCI-ACS Collaborative Study, 1209
cases, 1209 controls. Case-control study within the Washington
County CLUE Cohort Study.In 1974, over 8,000 male residents of
Washington County, Maryland, donated a blood sample and
completed a health questionnaire. IGF1 role. Prostate cancer
risk following benign prostatic hyperplasia in Sweden and
Denmark.86,626 Swedish BPH patients diagnosed during 1964-1983
and 86,683 Danish BPH patients diagnosed during 1977-1993” -
http://dceg.cancer.gov/prost-cancer.html
- Schizophrenia & Bipolar Disorder: "Extensive population and family
collections for schizophrenia and bipolar disorder." -
http://www.hopkinsmedicine.org/epigen/
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