Genetic Diversity
- ALFRED: "The ALlele FREquency Database A resource of
gene frequency data on human populations supported by the U. S.
National Science Foundation." -
http://alfred.med.yale.edu/alfred/index.asp
- Apolipoprotein E (APOE) allele distribution in the world.
Is APOE*4 a 'thrifty' allele?: “APOE is involved in the
development of certain pathological conditions. In particular,
the APOE*4 allele is a risk factor for susceptibility to
coronary artery disease (CAD) and Alzheimer's Disease (AD). In
the present study we analyzed the APOE allele distribution in
the world. The APOE*3 is the most frequent in all the human
groups,..” -
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10738542&query_hl=11
- Basic Population Genetics: "Extensive collection of
information about Population Genetics, including Theory,
History, Software, etc." -
http://www.dorak.info/genetics/popgen.html
- Coriell Identity Mapping Kit:
“Five highly polymorphic tetra-nucleotide microsatellites, FES/FPS,
vWA31, D22S417, D10S526, and D5S592, have been characterized by Coriell
scientific staff for genotyping purposes and for preparation of the Coriell
Identity Mapping Kit. Used as a set, these five microsatellites provide good
discrimination between samples, with a matching probability of approximately one
in three million." -
http://ccr.coriell.org/ccr/products/mskit.html
- Genetic Ancestry Tracing and The African Identity:
“article by Charles Rotimi, Nigerian and US geneticist about the
potentials, benefits and pitfalls of molecular genealogical
studies for African-Americans” -
http://scbe.stanford.edu/events/pdfs/rotimi.pdf
- The Genographic Project: "The Genographic Project, a global five-year study
collecting DNA from 100,000 indigenous peoples spanning five continents by some
of the world's top population geneticists and other leading experts who are
aiming to map the history of human migration via DNA, invites all members of the
public to take part. It aims at tracing the genetic lineage of various human
populations on the planet - to put it simply, to establish the degree of kinship
between the modern peoples. The $40 million privately funded initiative is a
collaboration between National Geographic magazine, IBM, and the Waitt Family
Foundation charity. IBM will also provide the computing infrastructure for the
project, using sophisticated analytical techniques to interpret the information
in the biobank and find patterns in the genetic data." -
https://www5.nationalgeographic.com/genographic/index.html
- History since the last Ice Age: International DNA Projects : "Y chromosome
haplogroups, due to the nonrecombining and easily analysed haploid nature of the
Y chromosome, and its pattern of male to male transmission, give unique
information about population history and, in patriarchal surnaming cultures,
about historical identity of surnames. Mitochondrial haplotypes are also easy to
determine and since mitochondrial DNA only transmits via the egg, gives high
resolution information about the female to female history of populations." -
http://freepages.genealogy.rootsweb.com/~allpoms/genetics3.html
- Human Genome Epidemiology Network, (HuGENet™) reviews:
“A HuGE Review identifies human genetic variations at one or
more loci, and describes what is known about the frequency of
these variants in different populations, identifies diseases
that these variants are associated with and summarizes the
magnitude of risks and associated risk factors, and evaluates
associated genetic tests. Reviews point to gaps in existing
epidemiologic and clinical knowledge, thus stimulating further
research in these areas. We invite authors to write reviews in
their area of expertise.” -
http://www.cdc.gov/genomics/hugenet/reviews.htm
- In the name of the father: surnames and genetics:
"Article explaining Y chromosome studies in relation to paternal
surnaming and tests of the origin of any particular surname." -
http://www.le.ac.uk/genetics/maj4/SurnamesForWeb.pdf
- Pattern of gradient of apolipoprotein E allele *4
frequencies in western Europe.: “The apolipoprotein E gene (APOE)
is located on chromosome 19. APOE*3 is the most common allele,
coding for the product E3; APOE*2 codes for an Arg-158-->Cys
substitution (E2), and APOE*4 codes for a Cys-112-->Arg product
(E4).We completed a meta-analysis of APOE 2, 3 and 4 allele
frequencies from 30 geographically defined populations in
Europe, including Iceland and Turkey.” -
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9057348&query_hl=11
- Perspectives on Molecular Evolution: "Beginning in
the 1960s, evolutionary biology was significantly transformed by
the incorporation of ideas and techniques from molecular
biology. This led to many novel views (and as many
controversies) about phylogenetic relationships, rates and
mechanisms of evolutionary change, and standards of inference
and hypothesis testing. This interactive website is devoted to
recounting, documenting, and analyzing the history of molecular
evolutionary biology. This is not just an activity for
historians and philosophers. We especially encourage
contributions and reactions from biologists. The site will grow
through the addition of topics (like those listed on the right),
each of which will include discussions, interviews, online
documents, bibliographies, and timelines. We hope that the site
will be useful for teaching as well as research." -
http://hrst.mit.edu/hrs/evolution/public/
- Population Genetics links: "Courses with Lecture
Notes, Outlines, and Educational Materials" -
http://www.geocities.com/CapeCanaveral/Lab/4709/popgen.htm
- Public Population Project in Genomics (P3G): "P3G is
a non-for-profit international consortium to promote
collaboration between researchers in the field of population
genomics. It has been launched in order to provide the
international population genomics community with the resources,
tools and know-how to facilitate data management for improved
methods of knowledge transfer and sharing. Its main objective
consists in the creation of an open, public and accessible
knowledge database. The motto is transparency and collaboration"
- http://www.p3gconsortium.org/
- PhyCom: "A Phylogenetic Community" -
http://www.yphy.org/phycom/index.php
- Quantitative genetics resources: "This list of
resources is maintained as an electronic supplement to our
forthcoming two volume textbook on Quantitative Genetics to be
published by Sinauer Associates. Links to web pages, particular
programs, and notes/comments on all issues in quantitative
genetics (i.e., animal breeding, plant breeding, evolutionary
genetics, human genetics) can be found under the appropriate
chapters for each volume." -
http://nitro.biosci.arizona.edu/zbook/book.html
- Sorenson Molecular Genealogy Foundation (SMGF) : “The
non-profit Sorenson Molecular Genealogy Foundation (SMGF) is
building the world's largest database of correlated genetic and
genealogical data. Our database uses sophisticated DNA analysis
to link individuals together, while maintaining strict
confidentiality of participants' information. DNA samples with
associated four-generation pedigree charts have already been
collected from over 50,000 volunteers by SMGF. Up to 170 genetic
markers (specific regions of DNA) on all the chromosomes are
analyzed for each individual. The corresponding pedigree chart
is also extended by staff genealogists as far as genealogical
databases allow; extended pedigrees currently include over one
million ancestral records.” -
http://smgf.org/about_smgf.html
- Uncovering African Roots: DNA Tests, New Technology
Reveal African Heritage: “NOT LONG AGO, an African American
trying to trace their genealogy came up against a seemingly
insurmountable obstacle: slavery. Even if ancestry could be
traced back through the slave years, it was considered virtually
impossible to determine where in Africa one's family originated.
Some time next year Howard University, USA plans to begin
offering genetic testing so Americans of African ancestry can
determine where on the continent their ancestors came from.
Howard University, a historically black college in Washington,
D.C., has assembled the largest collection of DNA records from
West and Central Africa in the world, some 3,800 samples in all.
The collection concentrates on ethnic groups in areas where most
slaves in the United States came from. Most blacks brought to
the U.S. came from what are now Nigeria, Benin, Togo, Ghana, and
Sierra Leone, all of which are in West Africa. Smaller numbers
came from Senegal, the Gambia, the Congo River basin, and
Angola.” -
http://www.infoplease.com/spot/slavery2.html