OEGE - Online Encyclopedia for Genetic Epidemiology studies

Chasman et al report a GWAS of migraine in a sample of 5122 cases and 18108 controls. Loci associated with migraine include: 1p36.32 (rs2651899, PRDM16), 2q37.1 (rs10166942, TRPM8) and 12q13.3 (rs11172113, LRP1). The first two of these were specific for migraine (rather than non-migraine) headache. Published in Nature Genetics

Sun et al report a GWAS of atopic dermatitis in a Chinese Han sample. They identify associated loci at 5q22.1 (TMEM232, SLC25A46) and 20q13.33 (TNFRSF6B, ZGPAT) and replicated a previously reported locus at 1q21.3 (FLG). Published in Nature Genetics

Martin et al report on a genome-wide association study of educational attainment (EA) and IQ. In a large discovery sample (n=9538) they found no association above their genome-wide significance threshold, which they suggest points to a highly polygenic basis of EA. Replication of the top 50 hits yielded one (on 11q14.1) associated with EA, but they conclude that this requires further replication. Published in PLoS One

Kim et al report association with chronic myeloid leukemia at loci in 6q25.1 and 17p11.1. They list candidate genes RMND1, AKAP12, ZBTB2, and WSB1 at those two loci. Published in Blood

Burdon et al report a GWAS for open-angle glaucoma blindness with associated loci including TMCO1 and CDKN2B-AS1. They also report that CDKN2A and CDKN2B expression are upregulated in retina of rat glaucoma model. Published in Nature Genetics

Duncan et al report a GWAS of bone mineral density. They replicate 21 of 26 previously reported BMD hits and highlight "suggestive association" near several other genes (CLCN7, GALNT3, IBSP, LTBP3, RSPO3, and SOX4). Published in PLoS Genetics

The INHANCE consortium present results of a genome-wide association study of upper aerodigestive tract cancers in Europeans. The authors describe two novel variants, one near HEL308/FAM175A (DNA repair related) and one near ALDH2. Previously reported variants in the ADH gene cluster were replicated in this study. Published in PLoS Genetics

The Coronary Artery Disease "C4D" Genetics consortium present results of a genome-wide association study of coronary artery disease in Europeans and South Asians. The authors describe five new candidate CAD loci in this publication: LIPA, PDGFD, ADAMTS7-MORF4L1, a locus on 7q22 (many genes) and KIAA1462. Published in Nature Genet

The NHLBI CARe consortium present results of a genome-wide association study of coronary heart disease in African Americans. No associated loci were unique to African American populations, all having been described previously for other populations. At known CHD loci, the differing LD patterns between this population and others enabled identification of polymorphisms more strongly associated with phenotype than those previously reported. Published in PLoS Genet

Kaplan et al present results of a genome-wide association study of circulating IGF-I and IGFBP-3 levels. SNPs in the IGFBP3 gene region associate with both IGFBP-3 and IGF-I levels. Other loci include SNPs near SORCS2 and SNPs near IGFALS. Published in Hum Mol Genet

Okada et al analyse the role of IL6 in inflammation and the regulation of serum C-reactive protein levels. Published in Hum Mol Genet

Painter et al identify a locus at 7p15.2 associated with endometriosis. Published in Nat Genet

Walsh et al use a genome-wide approach to identify copy number variants at differential levels in non-tumor cells of patients with neuroendocrine tumors. Published in Endocr Relat Cancer

Purdue et al use a genome-wide association approach to identify susceptibility loci near EPAS1 (chromosome 2p21) and intergenic on 11q13.3. Published in Nat Genet

Slager et al identify a new suceptibility locus for familial CLL at 6p21.3 near the HLA-DQA1 and HLA-DRB5 genes. Published in Blood