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Population Studies
(country then alphabetical order)
Countries:
Australia
- The Busselton Health Study: "is one of the longest running epidemiological
research programs in the world. The residents of the town of Busselton in the
south-west of Western Australia have been involved in a series of health surveys
since 1966. Busselton Health Study activities include:a series of
cross-sectional, whole-population health surveys in the town; continuing
followup of cross-sectional survey participants; collection of sera and DNA
samples; compilation of information on family relationships between survey
participants." -
http://bsn.uwa.edu.au/
- Joondalup Family Health Study: "The proposed Joondalup Family Health
Study would build on the experience of the Busselton Health Study, which has
provided 30 years of population-based health data and has led to improved health
outcomes in a number of chronic diseases such as asthma and cardiovascular
disease. The planned study will also have a strong focus on families and the
health of both children and adults." -
http://www.jfhs.org.au/about.html
-
The National Health and Medical Research Australian Twin
Registry (NHMRC ATR): "based at the Genetic
Epidemiology Laboratory of the Queensland Institute of Medical
Research in Melbourne, was founded in 1979 .In addition to
current studies on a diverse range of topics including
alcoholism, asthma, women's health, moliness and osteoarthritis,
there is a large body of historical data collected from the
twins over the past 15 years. Over 15,000 pairs of twins have
participated in various studies, and almost 40,000 relatives of
those twins." -
http://genepi.qimr.edu.au/
- WAIMR Laboratory for Genetic Epidemiology "Western Australian Genetic
Epidemiology Resource (WAGER); Western Australian DNA Bank; Western Australian
Cardiovascular Disease Consortium (WACVDC); Western Australian Sleep Health
Study; Western Australian Genome Health Project; Joondalup Family Health Study;
Western Australian Twin Register" -
http://www.genepi.com.au/main_projects
Austria
Canada
- CART@GENE:
“The CART@GENE project encompasses 50,000 adults in Quebec, Canada
between 25-74 years of age representing ≈1.2% in that age group. (Phase A
= 20,000 over 3 years) and studies maintenance of health and susceptibility to
common diseases such as cancer, diabetes, hypertension, arthritis, and others."
-
http://www.cartagene.qc.ca/
China
- Chinese National Twin Registry: “Chinese National
Twin Registry as a Resource for Genetic Epidemiologic Studies of
Common and Complex Diseases in China. To date (2002), we have
over 4500 twin pairs registered and about 700 twin pairs studied
for various metabolic traits (e.g., lipids, glucose, insulin,
etc.). The long-term plan of this program is to (1) establish a
population-based twin registry from several selected regions in
China for future studies of specific common complex diseases;
(2) conduct detailed phenotyping for clinical and intermediate
traits related to cardiovascular diseases; (3) expand studies of
twins to twin families by including their parents, siblings, and
offspring for genetic linkage and association studies; and (4)
follow up twins in the registry longitudinally.” -
http://www.ingentaconnect.com/content/aap/twr/2002/00000005/00000005/art00006
Denmark
- Danish Twin Registry:
“The Danish Twin Registry (DTR) is one of the oldest twin registries in
the world. It was established in the 1950’es with the aim of studying causes of
cancer, and through the years it has gradually been expanded so that it now
comprises twins born through more than 130 years." -
http://www.dtr.sdu.dk/?sideid=index&sprog=eng
- Inter99: "5,868 middle-aged white Danish subjects from the Inter99 cohort,
established at the Research Centre for Prevention and Health (4,441 subjects
with normal glucose tolerance [NGT], 495 subjects with impaired fasting glycemia
[IFG], 684 subjects with IGT, and 248 patients with screen-detected and
untreated type 2 diabetes), fasting and post–oral glucose tolerance test (OGTT)
glycemia and other quantitative traits. All participants from the Inter99 cohort
(including patients with treated type 2 diabetes; in total 5,965 middle-aged
white Danish subjects) were evaluated in a case-control study examining the
association between genotype and the metabolic syndrome according to 1999 WHO
standards." -
http://diabetes.diabetesjournals.org/cgi/content/full/54/10/3026
Estonia
- Estonian Genome Project: "In 2005 the gene bank
containes already the data over 10,000 gene donors. With the
increase of the number of gene donors to 100,000 within next
four years it will be suitable for many nested case-control
studies. The database will make it possible to carry out
research both in Estonia and outside to find links between
genes, environmental factors and common diseases (cancer,
diabetes, depression, cardio-vascular diseases, etc)" -
http://www.geenivaramu.ee/index.php?lang=eng&sub=58
Finland
- Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC)
Study: “The Alpha-Tocopherol, Beta-Carotene Cancer
Prevention (ATBC) Study was a cancer prevention trial conducted
by NCI and the National Public Health Institute of Finland from
1985 to 1993. The study was to determine whether certain vitamin
supplements would prevent lung cancer and other cancers in a
group of 29,133 male smokers 50-69 years old in Finland. The 50-
to 69-year-old participants took a pill daily for five to eight
years that contained one of the following: 50 milligrams (mg)
alpha-tocopherol (a form of vitamin E), 20 mg of beta-carotene
(a precursor of vitamin A), both, or a placebo (inactive pill
that looked like the vitamin). Questionnaire data and blood
samples were collected at baseline and during follow-up.
Incident cancer cases are identified annually through national
registers.” -
http://epi.grants.cancer.gov/BPC3/cohorts.html#plco
- Cardiovascular Risk in Young Finns Study: “DESIGN,
SETTING, AND PARTICIPANTS: Population-based, prospective cohort
study conducted at 5 centers in Finland among 2229 white adults
aged 24 to 39 years who were examined in childhood and
adolescence at ages 3 to 18 years in 1980 and reexamined 21
years later, between September 2001 and January 2002. MAIN
OUTCOME MEASURES: Association between cardiovascular risk
variables (levels of low-density lipoprotein cholesterol [LDL-C],
high-density lipoprotein cholesterol [HDL-C], and triglycerides;
LDL-C/HDL-C ratio; systolic and diastolic blood pressure; body
mass index; smoking) measured in childhood and adulthood and
common carotid artery IMT measured in adulthood." -
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14600186
Germany
- KORA-gen: “KORA research platform (Cooperative health
research in the Region of Augsburg, Southern Germany) has
evolved from the WHO MONICA study (Monitoring of Trends and
Determinants of Cardiovascular Disease). In total, four
population based health surveys have been conducted between 1984
and 2000 with 18000 participants in the age range of 25 to 74
years, and a biological specimen bank was established.
Continuing regular follow-up investigations have collected
information on sociodemography, general medical history,
environmental factors, smoking, nutrition, alcohol consumption,
and various laboratory parameters." -
http://www0.gsf.de/kora-gen/index_e.html
Holland
- Dutch Twin Registry:
“Het
Nederlands Tweelingen Register (kortweg NTR) werd op 1 februari 1987 aan de
Vrije Universiteit te Amsterdam opgericht ten behoeve van
wetenschappelijk onderzoek. Onderzoek bij tweelingen en hun familieleden kan
namelijk inzicht verschaffen in de mate waarin verschillen tussen mensen bepaald
worden door erfelijke of omgevingsinvloeden. Door de continue hulp van de
tweelingen en hun families die bij het NTR staan ingeschreven onderzoekt het NTR
de invloed van genen en omgeving op onder andere de ontwikkeling van de hersenen,
intelligentie, probleemgedrag van kinderen, gezondheid en leefgewoonten, angst
en depressie, persoonlijkheid en veroudering." -
http://www.tweelingenregister.org/
Iceland
- AGES - Age, Gene/Environment Susceptibility Study
"The Age, Gene/Environment Susceptibility (AGES Reykjavik) Study
was initiated to examine genetic susceptibility and
gene/environment interaction as these contribute to phenotypes
common in old age, a collaborative study between the National
Institute on Aging, NIH and the Icelandic Heart Association. The
AGES will phenotype the surviving 12,000 members of the
Reykjavik Study cohort (now 67 years and older) for quantitative
traits related to diseases and conditions of old age, and
collect genetic and other biologic specimens The IHA-established
Reykjavik Study, a longitudinal study from 1967 to 1994 of over
20,000 participants collected mid-life data on cardiovascular
traits such as blood pressure and cholesterol." -
http://www.hjarta.is/EN/FrontPage.aspx?GroupId=346
International
- EURO-BLCS Study: "The euro-blcs study sets out to explore the evolution of
cardiovascular morbidity, mortality and intermediate disease markers throughout
the lifecourse in children, adolescents, young adults, middle-aged and elderly
people as a means of identifying high risk groups and biological markers
amenable to early intervention and prevention."
http://www1.imperial.ac.uk/medicine/about/divisions/ephpc/eph/projects/cdel/euroblcs/default.html
- European Prospective Investigation of Cancer: “EPIC
was designed to investigate the relationships between diet,
nutritional status, lifestyle and environmental factors and the
incidence of cancer and other chronic diseases. EPIC is the
largest study of diet and health ever undertaken, having
recruited over half a million (520,000) people in ten European
countries: Denmark, France, Germany, Greece, Italy, The
Netherlands, Norway, Spain, Sweden and the United Kingdom
(select a country from the map). Within these countries EPIC
research scientists are based in 23 centre. is coordinated by Dr
Elio Riboli, Chief of the Nutrition and Hormones Group at the
International Agency for Research on Cancer (IARC, which is part
of the World Health Organization) in Lyon, France.” -
http://www.iarc.fr/epic/index.html
- Genetics of Healthy Ageing (GEHA): “(2004)The genetic
analysis will be performed by 9 high throughput platforms,
within the framework of a centralized database. The working plan
of this IP is to: (i) collect an unprecedented number (2800) of
long-lived (90+) sibpairs from 11 European countries (including
Israel); (ii) perform a genome scan by microsatellites in all
the sibpairs (a total of 5600 individuals) (iii) study in cases
(i.e. the 2800 probands of the sibpairs) and controls (2800
young people) , the three genomic regions (chromosome 4,
D4S1564, chromosome 11, 11.p15.5, and chromosome 19, around APOE)
which were identified in previous studies as to be involved in
aging and longevity.” -
http://www.geha.unibo.it/page_display.asp?pid=13
- GenomEUtwin: “The participating 8 twin cohorts form a
collection of over 0.6 million pairs of twins. Tens of thousands
of DNA samples with informed consents for genetic studies of
common diseases have already been stored from these
population-based twin cohorts. The population cohorts used in
the Genomeutwin study consist of Danish, Finnish, Italian, Dutch
and Swedish twins and the MORGAM population cohort." -
http://www.genomeutwin.org/index.htm
- MORGAM: “The MORGAM Project is a multinational
collaborative study to explore the relationships between the
development of cardiovascular diseases and their classic and
genetic risk factors. This is done through follow-up of cohorts
examined in the MONICA risk factor surveys and other studies. As
many of the participating centres have collected DNA in their
surveys, gene-environment interactions can be assessed in a
large case-cohort study. The MORGAM Project is part of
GenomEUtwin, a Network of Excellence for Genomics in Europe." -
http://www.ktl.fi/morgam/
- Twin Registers Worldwide - links to many countries:
“There are many websites with information on twins, research
involving twins, and multiple birth organisations. We have
listed some sites below that you may find interesting. Please
note that ISTS is not responsible for the content of the sites
listed and provides these addresses for your information and
interest only. Due to the large number of sites, it is
impossible to closely monitor all of them. If you feel that
something listed on any site is inappropriate or if you would
like to have a site considered for addition, please notify us by
emailing us at ists@qimr.edu.au.” -
http://www.ists.qimr.edu.au/links.html#Twin%20reg
Italy
- Italian Twin Registry:
“The Italian Twin Registry is a population register comprising pairs of
twins who accept to participate in medical and scientific
research activities aimed at improving the health of the whole
population. It was created in 2000 and today it is a
well-established scientific reality involving more than 9000
twins. The information contained in the registry is accessible
to institutional research groups which intend to assess the
relative weight of genetic, environmental and behavioural
factors in the etiopathogenesis of multi-factorial diseases with
the purpose of estimating, through pilot studies based on the
twin database, the genetic load on the Italian population of
some autoimmune, dysmetabolic diseases related to ageing and
behavioural changes.” “Responsabile: Antonia Stazi, epidemiologa. stazi@iss.it" -
http://www.gemelli.iss.it/
Latvia
- Latvian National Project: “launched on January 1,
2001. The main objective of the project is to collect sufficient
amount of genetic information of the Latvian population and
compare this data with the clinical information and the
information available about specific pedigrees. The direct
outcome of the project for each individual will be seen in the
possibility to consider his/her risks to develop certain
diseases due to their genetic features and to eliminate these
risks, particularly by application of the individual therapy
based on genetic characteristics of the patient” -
http://bmc.biomed.lu.lv/gene/
Norway
- Norwegian Biobank: “BIOBANKS FOR HEALTH (also known
as BIOHEALTH NORWAY) is a large population based cohort
established for genetic epidemiologic research. The collection
of samples and information is still ongoing. When completed, the
cohort will comprise biological samples and standardised health
and exposure data from 450.000 Norwegian individuals of all
ages, corresponding to approximately 1/10 of the Norwegian
population." -
http://www.fhi.no/eway/default0.asp?pid=225&MainArea_4807=4828:0:15,2816:1:0:0:4807;4809;::0:0:0
- The Norwegian Mother and Child Cohort Study: “The
target population comprises of all pregnant women and the
fathers in Norway during a 4-5 year period. The sample size is
100,000 women. If this number has not been reached by the year
2005, data collection may continue until the sample size is
reached. Exposure variables include genes, psychosocial factors,
infections, use of medication, nutrition, life styles,
occupational exposure, use of health services, substance abuse
and socioeconomic factors as well as chemical and physical
factors in the environment. Health variables include maternal
and paternal history and health outcomes for the mother and
child detected during and after pregnancy. All blood samples are
sent to the National Institute of Public Health in Oslo where a
biobank is organized for the storing and processing of all
samples. Extraction and processing of DNA for genetic studies
are important issues.” -
http://www.fhi.no/custom/getmessage.asp?objectid=51488&moduleid=360
Poland
- Polish Centenarian Program: “Since the beginning of
the project more than 350 centenarians have been visited and
genetic material has been collected from many of them and from
79 people of 65 years old. The DNA, RNA, and immortalised
lymphocytes bank consists of samples taken from both
centenarians and healthy subjects as well as from Alzheimer
disease patients (gDNA 369, cDNA 233, immortalized cell lines
247).” -
http://www.iimcb.gov.pl/kuznicki_lab.php
Sweden
- LifeGene: “Mar 01, 2005 Swedish LifeGene Project The
Swedes have proposed what they are calling the "most
comprehensive medical project" since the human genome. The
project has a tentative name, LifeGene, and the goal is to
combine "biological information with lifestyle data" from a
population of 500,000 people in order to get a "greater
understanding of the interplay between heredity, lifestyle and
the environment in relation to the most common diseases."“ -
http://jrb.typepad.com/personalgenome/2005/03/swedish_lifegen.html
- The Swedish Twin Registry "is the largest twin register in the world and
includes more than 140,000 twins. The registry covers three different age
cohorts, the older cohort, the middle cohort, and the younger cohort. The
purpose of twin studies is to study the relative importance of genetic and
environmental influences for behavioral characteristics and diseases. There are
about 30 ongoing research projects using data from the Swedish Twin Registry." -
http://www.meb.ki.se/twinreg/index_en.html
United Kingdom
- The 1970 British Cohort Study – held by the Centre for Longitudinal Studies, http://www.cls.ioe.ac.uk/text.asp?section=000100010002
- ALSPAC – The Avon Longitudinal Study of Parents and Children (also known as 'Children of the 90s'). Follows ~10,000
subjects born 1991-92. Studies of growth, body composition, insulin
sensitivity and insulin secretion during childhood. "This is aimed at identifying ways in which to optimise the health and development of children.”
http://www.alspac.bris.ac.uk/welcome/index.shtml
- British Women's Heart and Health Study (BWHHS):
"BWHHS is a prospective cohort study of heart disease in British
women between the ages of 60 and 79. It is funded by the
Department of Health, the British Heart Foundation and the
Stroke Association. Field sampling phase was completed on
schedule in March 2001. The study team are based at the
University of Bristol, in the Department of Social Medicine." -
http://www.epi.bris.ac.uk/bwhhs/index.htm
- Cambridge infant growth study. "Ongoing recruitment of ~1,000 infants
recruited in pregnancy, with assessment of maternal oral glucose tolerance,
insulin sensitivity and insulin sensitivity, and repeated assessments of
offspring body composition infancy".
http://www.medschl.cam.ac.uk/paediatrics/
- European Youth Heart Study. "2,000 children aged 9 or 15 yr from Denmark,
Portugal, Estonia, and Norway, assessed for growth, physical activity,
fasting insulin sensitivity, and other markers of adult disease".
http://www.prevnut.ki.se/eyhs.htm
- The National Child Development Study (1958 cohort) – held by the Centre for Longitudinal Studies, http://www.cls.ioe.ac.uk/text.asp?section=000100010002
- The National Research Register (NRR) UK: "is a database of ongoing and
recently completed research projects funded by, or of interest to, the United
Kingdom's National Health Service (NHS. About 350 organisations (NHS Trusts,
national and regional funding programmes, universities, charities) in England,
Scotland and Wales contribute data which is updated every three months. The
Register provides a reasonable record of projects that were ongoing from early
2000 onwards..." - http://www.nrr.nhs.uk/
- Second Northwick Park Heart Study - NPHSII: "This
study was established in 1989, and is an ongoing survey of 3000
middle aged men who were in good health when first seen. It is a
long-term investigation of heart attack, a condition caused by
narrowing of the arteries in the heart (coronary arteries) and
eventual obstruction by blood clot (thrombosis)." -
http://www.mrc-gprf.ac.uk/maindocs/research/display.s?nphsii
- Southampton Women's Survey. "3,000 infants recruited by 2006, with maternal
dietary data during pre-pregnancy and pregnancy, and postnatal follow-up".
http://www.mrc.soton.ac.uk/sws/involve.htm
- Twin Research UK: “We provide a list of the vast majority of phenotypes
that have been collected on at least 1,000 individuals in the Twins UK study" -
http://www.twin-research.ac.uk/
- UK Biobank – “a unique resource for ethical research into genetic and environmental factors that impact on human health and disease, to improve the health of future generations.”
http://www.ukbiobank.ac.uk/
- The UK Millennium Cohort Study – held by the Centre for Longitudinal Studies,
http://www.cls.ioe.ac.uk/text.asp?section=000100010002
United States of America
- American Cancer Society Cancer Prevention Study-II
Nutrition Cohort (ACS CPS-II): “The American Cancer Society
Cancer Prevention Study II Nutrition Cohort (CPS-II) was
established in 1992. The cohort includes more than 86,000 men
and 97,000 women who completed a mailed questionnaire in 1992.
Starting in 1997, follow-up questionnaires have been sent to
surviving cohort members every other year to update exposure
information and to ascertain occurrence of new cases of cancer;
a 90% response rate was achieved for follow-up questionnaires in
1997 and 1999. Incident cancers are verified through medical
records, state cancer registries, or death certificates. From
June 1998 through June 2001, blood samples were collected from a
subgroup of 39,376 cohort members. The CPS-II has accrued 500
cases of breast cancer (and their age and race-matched controls)
and 1,450 cases of prostate cancer (and their age and
race-matched controls) who were diagnosed after completing the
1992 questionnaire and who gave a single blood sample during the
period June 1998 through June 2001.” -
http://epi.grants.cancer.gov/BPC3/cohorts.html
- CARDIA Study: “The Coronary Artery Risk Development
in Young Adults (CARDIA) Study is a study examining how heart
disease develops in adults. It began in 1986 with a group of
5115 black and white men and women aged 18-30 years. The
participants were selected so that there would be approximately
the same number of people in subgroups of race, gender,
education (high school or less and more than high school) and
age (18-24 and 25-30) in Birmingham, AL; Chicago, IL;
Minneapolis, MN; and Oakland, CA. These same participants were
asked to participate in follow-up examinations during 1987-1988
(Year 2), 1990-1991 (Year 5), 1992-1993 (Year 7), 1995-1996
(Year 10), and 2000-2001 (Year 15). A majority of the group has
been examined at each of the follow-up examinations (90%, 86%,
81%, 79%, and 74%, respectively). Another follow-up exam in
planned for 2005-2006 (Year 20). There are stored biologic
specimens collected at each cohort visit, including DNA and
immortalized cell lines.” -
http://www.cardia.dopm.uab.edu/o_brde.htm
- Flint Men's Health Study (African-Americans /prostate
cancer): “The study began collecting data in 1996 and
identified 817 eligible African-American men ages 40-79 to
participate. The study subjects were recruited from Flint, Mich.,
an urban area north of Detroit. Of the eligible group, 369
participants underwent an interview, clinical exam and serum
test. Researchers contacted the participants again in 2000 for
further testing; 183 took part in the second wave.” -
http://www.mydna.com/health/prostate_cancer/ethnicity/msr1pc.html
- Framingham - Cardiogenomics Program - Harvard: “149
cardiovascular risk genes SNP scanned, typed and analysed in the
Framingham Heart Study. Currently comprehensively characterizing
common genetic variation (linkage disequilibrium [LD] structure)
in 52 candidate genes and identifying common missense variants
in an additional 150 candidate genes identified by parallel
mouse and human studies, and determining which of these
genotypes are associated with echocardiographic measures of left
ventricular size and function among members of the Framingham
Heart Study (FHS).” -
http://cardiogenomics.med.harvard.edu/genes/gene-list
- Georgia Centenarian Study: “Phase 1 (1988-1992)A
cross-sectional study examining unique adaptational
characteristics of community-dwelling and cognitively-intact
centenarians, octogenarians, and sexagenarians in Georgia. A
collaboration among The University of Georgia, Medical College
of Georgia, and Iowa State University. Funded by NIMH.Phase 2
(1992-1998)A study of longitudinal changes in adaptational
capacity among the three cohorts. Funded by NIMH.Phase 3
(2001-2006)A study to identify and isolate longevity genes,
neuropathology, and functional capacity of a population-based
sample of centenarians and controls in 31 counties in Northern
Georgia. A collaboration among The University of Georgia,
Louisiana State University, Boston University, University of
Kentucky, Emory University, Duke University, Rosalind Franklin
University of Medicine and Science, Iowa State University and
University of Michigan. Funded by NIA” -
http://www.geron.uga.edu/research/centenarianstudy.php
- Harvard Cohorts participating in breast and prostate
cancer study BPC3 (1): “There are four Harvard Cohorts
participating in the BPC3 Study. The Physicians' Health Study
(PHS) was a randomized trial of low-dose aspirin and
beta-carotene in the prevention of cardiovascular disease and
cancer in men aged 40-84 at entry in 1982. This population was
supplemented in 1999 with male physicians aged 50 years or
older; more than 20,000 men provided baseline blood samples.” -
http://epi.grants.cancer.gov/BPC3/cohorts.html
- Harvard Cohorts participating in breast and prostate
cancer study BPC3 (2): “The Nurses' Health Study (NHS)
consists of 121,700 women enrolled in 1976. In 1989-90, 32,826
participants provided a blood sample.” -
http://epi.grants.cancer.gov/BPC3/cohorts.html
- Harvard Cohorts participating in breast and prostate
cancer study BPC3 (3): “The Health Professionals Follow-up
Study (HPFS) consists of 51,529 non-physician health
professionals (e.g., dentists and veterinarians) of whom 18,410
gave a blood sample in 1993 and 15,100 gave buccal cell samples
in 1999.” -
http://epi.grants.cancer.gov/BPC3/cohorts.html
- Harvard Cohorts participating in breast and prostate
cancer study BPC3 (4): “The Women's Health Study (WHS) is a
randomized trial of low-dose aspirin and vitamin E for the
prevention of cardiovascular disease and cancer among 39,876
female health professionals aged 45 years or older at baseline
in 1993; 28,263 women provided blood samples prior to
randomization.” -
http://epi.grants.cancer.gov/BPC3/cohorts.html
- Multiethnic Cohort Study (Hawaii and Los Angeles):
“The Multiethnic/Minority Cohort Study was established in Hawaii
and Los Angeles in 1993-1996 to explore the relationship of diet
and lifestyle to cancer. 215,000 men and women primarily of
African-American, Japanese, Latino, Native Hawaiian, and
Caucasian origin were enrolled, a unique ethnic diversity with
representation of minority populations. Each participant
completed a 26-page mail questionnaire that included an
extensive quantitative diet history, as well as other
demographic, medical, and lifestyle information. Multiple
24-hour diet recalls were collected on more than 2,000 of the
participants for calibration. During 1998-2003, a brief
follow-up questionnaire was completed by more than 80% of the
participants; in the current period of 2003-2008, the baseline
dietary questionnaire will be repeated. More than 25,000 cases
of breast, prostate, colorectal, and lung cancer are expected by
2007. In addition, biochemical measurements on 750 members of
the cohort will be used.” -
http://epi.grants.cancer.gov/ResPort/Multiethnic.html
- National Children’s Study (USA): “The goal is to
follow 100,000 children across 96 US locations from before birth
through age 21. The Study Plan focuses on several priority
health themes: outcomes of pregnancy, child growth and
development, injury, asthma, and psychological and emotional
health." -
http://nationalchildrensstudy.gov/
- National Health and Nutrition Examination Survey (NHANES):
“NHANES 1999-2003 Survey: The current NHANES survey began in
1999. We have obtained DNA from whole blood specimens obtained
from 8,000 subjects aged 20 yrs and older. These additional
8,000 DNA samples will significantly expand the existing NHANES
DNA bank and will be an important resource for intramural (CDC)
and extramural genetic research programs.” -
http://www.cdc.gov/nchs/nhanes.htm
- Northwestern University Hospital DNA Bank, Chicago:
“Northwestern University has launched the Chicago area's first
hospital gene bank and hopes to eventually recruit as many as
100,000 people willing to donate their DNA in the interest of
science. NUgene will use DNA samples and personal health
information from volunteers, plus genotypic information, to
search out genes that play a role in diseases and then to
determine personalized treatments, according to Northwestern
officials. The university is the second institution (after
Marshfield) in the U.S. to announce plans for such a gene bank.”
- http://www.nugene.org/
- Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer
Screening Trial (NCI): “The Prostate, Lung, Colorectal, and
Ovarian (PLCO) Cancer Screening Trial is a multi-institution
study sponsored and coordinated by NCI. The PLCO has enrolled
more than 154,000 men and women in a large-scale clinical trial
to determine whether certain cancer screening tests reduce
deaths from prostate, lung, colorectal, and ovarian cancer.
Participants 55-74 joined the trial between 1992 and 2001 at 10
centers across the country. Half of these participants were
selected by chance to receive specific screening tests and half
receive routine care by their personal health care providers.
All participants provide regular updates on a variety of health
measurements in an annual questionnaire, as well as blood
samples for use in studies of biologic markers of cancer risk.
Half of participants in the screening arm have had blood samples
taken at baseline.” -
http://epi.grants.cancer.gov/BPC3/cohorts.html#plco
- Study of Women's Health Across the Nation (SWAN):
“SWAN has seven clinical study sites located in six states, two
in California, and one each in Illinois, Massachusetts,
Michigan, New Jersey and Pennsylvania. The SWAN cohort was
recruited in 1996/7 and consists of 3302 African American,
Caucasian, Chinese American, Hispanic and Japanese American
women. Cohort members complete an annual clinic visit. Detailed
follow up information on the website. The SWAN DNA Repository
currently contains extracted diluted DNA from ~ 1450 SWAN
participants. EB transformed B-lymphocytes for genomic or
proteomic studies are available.” -
http://www.swanrepository.org/
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