equilibrium calculator including analysis for ascertainment bias
equilibrium test calculator for biallelic markers (SNPs, indels etc),
including analysis for ascertainment bias for dominant/recessive models (due to biological or technial causes)
Enter observed counts for each genotype, then click "Calculate". (Copyright
TRG, SR, INMD, 2008)
If you use this web-tool please cite:
Santiago Rodriguez, Tom R. Gaunt and Ian N. M. Day.
Hardy-Weinberg Equilibrium Testing of Biological Ascertainment for Mendelian Randomization Studies. American Journal of Epidemiology
Advance Access published on January 6, 2009, DOI 10.1093/aje/kwn359.
refers to chi-squared
- The X2
value indicates the difference between expected and observed values for
- The likelihood of observing these differences
by chance can be determined from a X2
table (1 d.f.), a brief example of which is above
- Ascertainment bias (biological or technical reasons) may cause gains or losses in observed counts. This calculator indicates the expected counts under HWE if gains or losses have occured in one genotype group (dominant/recessive model) in addition to the conventional analysis which distributes gains/losses across all three genotype groups